Knock'Em Out 是一款物理驱动的多人乱斗游戏，玩家操控 BOXI 角色，用整个身体和对手缠斗。战斗的重点是把对手拆散，同时保住自己的身体部件。掉了一条手臂只是擦伤，掉了另一条也是轻伤，连腿都没了就用头撞。场景里布满了各种陷阱和武器，把对手引到陷阱上是取胜的常用手段。每个场景都有不同的地形和机关，角色可以跑酷、跳跃，在侧视角的关卡里周旋。
游戏提供分屏多人模式和在线模式，也支持 Remote Play Together。可用的模式包括：Deathmatch，把所有玩家击倒，直到自己成为最后站着的人；Bomb Tag，躲避拿着炸弹的玩家，最后存活者获胜；Title Champion，抢下头衔并守住它，成为冠军。模式规模从 2 对 2 到最多 8 人混战不等。操作可以用手柄，也可以用键盘。
Boxi 角色支持自定义，可以按自己的喜好调整外观。游戏带有成就系统，随对局推进解锁。战斗带有血腥表现，画面风格色彩鲜明、偏搞笑，但拆解身体的场面比较直接，介意这类表现的人需要留意。
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